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Journal: Journal of medicinal chemistry
Article Title: Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome
doi: 10.1021/acs.jmedchem.1c00419
Figure Lengend Snippet: Polyamine levels in wild-type (a: CMS-24949) and SMS mutant (b: CMS-26559, c: CMS-6233, and d: CMS-23916) fibroblast cell lines with or without treatment of Spm or prodrug 1 (5 μM) in the presence of AG (1 mM) after 72 h incubation at 37 °C. Values represent data from the experiment performed in triplicates ± SD, *p < 0.05, *** p < 0.001, **** p < 0.0001.
Article Snippet: The authors wish to thank Dr. Charles Schwartz at the
Techniques: Mutagenesis, Incubation
Journal: Journal of medicinal chemistry
Article Title: Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome
doi: 10.1021/acs.jmedchem.1c00419
Figure Lengend Snippet: Polyamine levels in CMS-23916 (mutant) fibroblast cell lines untreated (UT) or treated with prodrug 1 (5 μM) only, NAC (2 mM) only, or a combination of prodrug 1 (5 μM) and NAC (2 mM). Values represent data from the experiment performed in triplicates ± S.D. *p < 0.05.
Article Snippet: The authors wish to thank Dr. Charles Schwartz at the
Techniques: Mutagenesis